Product Name :
STIM1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
D11S4896E antibody GOK antibody OTTHUMP00000164512 antibody OTTHUMP00000229140 antibody OTTHUMP00000230742 antibody SIM antibody STIM 1 antibody STIM1 antibody Stim1 stromal interaction molecule 1 antibody STIM1_HUMAN antibody 展开
Function :
Ca2+ influx is essential for a variety of cellular functions, including secretion and transcription. Stromal interaction molecule 1 (Stim1) is a ubiquitously expressed cell surface transmembrane glycoprotein that plays a role in mediating Ca2+ influx following the depletion of intracellular Ca2+ stores. Stim1 functions in the endoplasmic reticulum (ER) where it acts as a Ca2+ sensor via its EF-hand domain, causing large conformational changes.2,3-Dihydropyran-6-one site When Ca2+ levels drop, Stim1 translocates from the ER to the plasma membrane, where it activates the calcium release-activated calcium (CRAC) channel subunit, TMEM142A/Orai1.2096419-56-4 Order Stim2 is a potent inhibitor of Stim1-mediated, store-operated calcium (SOC) entry. Stim1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions.PMID:33509045
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Amino acids 441-620 mapping near the C-terminus of Stim1 of human origin.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IP, IF, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃
Storage buffer solution:
1.0 ml of PBS with
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
86kDa
Positive control :
293T, A-10, human cerebellum tissue