Product Name :
2-Amino Adenosine (CAS 2096-10-8)
Synonym :
Application :
2-Amino Adenosine is an inhibitor or a substrate of adenosine kinase
CAS:
2096-10-8
Purity:
97%
Molecular Weight:
282.26
Formula :
C10H14N6O4
Physical state:
Solid
solubility :
Soluble in water, methanol, and DMSO.
Shipping Condition :
Store at room temperature
Melting point:
252° C (lit.)
SMILES:
C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)N
References:
:7-Functionalized 7-deazapurine ribonucleosides related to 2-aminoadenosine, guanosine, and xanthosine: glycosylation of pyrrolo[2,3-d]pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose. | Seela, F. and Peng, X. 2006. J Org Chem. 71: 81-90. PMID: 16388621Antisense probes containing 2-aminoadenosine allow efficient depletion of U5 snRNP from HeLa splicing extracts. | Lamm, GM., et al. 1991. Nucleic Acids Res. 19: 3193-8. PMID: 1648201An efficient process for synthesis of 2′-O-methyl and 3′-O-methyl guanosine from 2-aminoadenosine using diazomethane and the catalyst stannous chloride. | Kore, AR., et al. 2006. Nucleosides Nucleotides Nucleic Acids. 25: 307-14. PMID: 16629123New synthetic routes to synthons suitable for 2′-O-allyloligoribonucleotide assembly. | Sproat, BS., et al. 1991. Nucleic Acids Res. 19: 733-8. PMID: 1708121Pyrazolo[3,4-d]pyrimidine ribonucleosides related to 2-aminoadenosine and isoguanosine: synthesis, deamination and tautomerism. | Seela, F. and Xu, K. 2007. Org Biomol Chem. 5: 3034-45. PMID: 17728871Synthesis study of 2′-O-(2-methoxyethyl)-purine derivatives. | Sivets, GG. 2007. Nucleosides Nucleotides Nucleic Acids. 26: 1237-40. PMID: 18066759One-electron reduction of 8-bromo-2-aminoadenosine in the aqueous phase: radiation chemical and DFT studies of the mechanism. | Kaloudis, P., et al. 2008. J Phys Chem B. 112: 5209-17. PMID: 18373377Use of base-modified duplex-stabilizing deoxynucleoside 5′-triphosphates to enhance the hybridization properties of primers and probes in detection polymerase chain reaction. | Kutyavin, IV. 2008. Biochemistry. 47: 13666-73. PMID: 19046073[Affinity capture of specific DNA fragments with the use of short synthetic sequences]. | Mikhalov, VS., et al. 2013. Bioorg Khim. 39: 81-6. PMID: 23844509Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates.Buy2′-O-MOE-U | Rovira, AR.Buy3-(Hydroxymethyl)pyrrolidin-2-one , et al.PMID:33626991 2017. Chem Sci. 8: 2983-2993. PMID: 28451365Dye-conjugated complementary lipophilic nucleosides as useful probes to study association processes by fluorescence resonance energy transfer. | Mayoral, MJ., et al. 2017. Org Biomol Chem. 15: 7558-7565. PMID: 28857106Fluorescing Isofunctional Ribonucleosides: Assessing Adenosine Deaminase Activity and Inhibition. | Ludford, PT., et al. 2019. Chembiochem. 20: 718-726. PMID: 30566279Intrinsic Contributions of 2′-Hydroxyl to the Hydration of Nucleosides at the Monomeric Level. | Wang, Z., et al. 2020. Chemistry. 26: 17046-17055. PMID: 32786015