Also known as: Pauson-Khand cycloaddition
The Pauson-Khand reaction is an organic reaction used to convert an alkyne and alkene to a substituted cyclopentenone under an atmosphere of carbon monoxide and a dicobalt complex catalyst. Ruphos pd(crotyl)cl Order This 2+2+1 cycloaddition reaction begins with the addition of the alkyne to the metal complex followed by ligand substitution of the alkene to expel a CO molecule. Buy1,3-Cyclopentanedione Alkene insertion follows and a subsequent CO insertion results in the formation of a carbonyl group. A series of reductive eliminations then yield the final cyclopentenone product and regenerates the cobalt catalyst. [1][2][3]
Mechanism
References:
| 1. |
Cabot, R.; Lledó, A.; Revés, M.; Riera, A.; Verdaguer, X. Organometallics 2007, 26, 1134–1142.
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| 2. |
Yamanaka, M.; Nakamura, E. J. Am. Chem. Soc. 2001, 123, 1703–1708.
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| 3. |
Magnus, P.; Principe, L. M. Tetrahedron Letters 1985, 26, 4851–4854.
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