Product Name :
2-Methoxy-antimycin A
Synonym :
Application :
2-Methoxy-antimycin A3 is induces apoptosis in cancer cells by inhibition of Bcl-xL and Bcl-2
CAS:
Purity:
Molecular Weight:
534.60
Formula :
C27H38N2O9
Physical state:
Solid
solubility :
Soluble in DMSO (10 mM), and ethanol (10 mM).
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
CCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)OC)C)OC(=O)CC(C)C
References:
:Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. | Tzung, SP., et al. 2001. Nat Cell Biol. 3: 183-91. PMID: 11175751Real-time monitoring of lactate extrusion and glucose consumption of cultured cells using a lab-on-valve system. | Schulz, CM., et al. 2002. Analyst. 127: 1583-8. PMID: 12537364The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics. | Liu, W., et al. 2003. Curr Med Chem Anticancer Agents. 3: 217-23. PMID: 12769779Bcl-2-related proteins as drug targets. | O′Neill, JW. and Hockenbery, DM. 2003. Curr Med Chem. 10: 1553-62. PMID: 12871126Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family. | Shangary, S. and Johnson, DE. 2003.Formula of 3-Bromo-1-naphthoic acid Leukemia.3-Fluoro-2-methyl-6-nitropyridine supplier 17: 1470-81.PMID:33723743 PMID: 12886234Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy. | O′Neill, J., et al. 2004. Biochim Biophys Acta. 1705: 43-51. PMID: 15585172Targeted therapies for epithelial cancers: in vivo efficacy of the BCL-2/BCL-XL inhibitor 2-MeAA. | Schwartz, PS. and Hockenbery, DM. 2007. Cancer Biol Ther. 6: 465-6. PMID: 174710262-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition. | Schwartz, PS., et al. 2007. Mol Cancer Ther. 6: 2073-80. PMID: 17620436Piercing the armor of hepatobiliary cancer: Bcl-2 homology domain 3 (BH3) mimetics and cell death. | Mott, JL. and Gores, GJ. 2007. Hepatology. 46: 906-11. PMID: 17654739Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. | Fath, MA., et al. 2009. Cancer Biol Ther. 8: 1228-36. PMID: 19411865Combining 2-deoxy-D-glucose with electron transport chain blockers: a double-edged sword. | Boutros, J. and Almasan, A. 2009. Cancer Biol Ther. 8: 1237-8. PMID: 19458493Antimycin A18 produced by an endophytic Streptomyces albidoflavus isolated from a mangrove plant. | Yan, LL., et al. 2010. J Antibiot (Tokyo). 63: 259-61. PMID: 20300130Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. | Albershardt, TC., et al. 2011. J Biol Chem. 286: 24882-95. PMID: 21628457